Distinct AMPA-Type Glutamatergic Synapses in Developing Rat CA1 Hippocampus
نویسندگان
چکیده
منابع مشابه
Distinct AMPA-type glutamatergic synapses in developing rat CA1 hippocampus.
We assessed synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) properties during synaptogenesis to describe the development of individual glutamatergic synapses on rat hippocampal CA1 principal neurons. Pharmacologically isolated AMPAR-mediated glutamatergic synaptic currents [evoked by stimulation of the Schaffer Collateral pathway, excitatory postsynaptic currents (EP...
متن کاملDistinct AMPA - type glutamatergic synapses in developing rat CA 1 hippocampus 1
(246/250 words) 16 We assessed synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate 17 receptor (AMPAR) properties during synaptogenesis in order to describe the 18 development of individual glutamatergic synapses on rat hippocampal CA1 principal 19 neurons. Pharmacologically isolated AMPAR-mediated glutamatergic synaptic currents 20 (evoked by stimulation of the Schaffer Collateral pathw...
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Rat perinatal (E20-P0) CA1 pyramidal neurons were either synaptically active or silent. We show here that, during this developmental period, active but not silent cells form recurrent axon-collaterals that invade the radiatum and the lacunosum moleculare strata. These recurrents were never observed in adult rats. We propose that these transient recurrent axons may participate in the activity-de...
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During postnatal development of CA1 pyramidal neurons, GABAergic synapses are excitatory and established prior to glutamatergic synapses. As interneurons are generated before pyramidal cells, we have tested the hypothesis that the GABAergic interneuronal network is operative before glutamate pyramidal neurons and provides the initial patterns of activity. We patch-clamp recorded interneurons in...
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In the developing hippocampus, experiments using whole cell recordings have shown that a small number of synaptic activations can convert many glutamate synapses to AMPA silent synapses. This depression of AMPA signaling is induced by low-frequency (0.05-0.2 Hz) activation, does not require N-methyl-D-aspartate or metabotropic glutamate receptor activation for its induction, and does not readil...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2010
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00099.2010